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Tirzepatide works through the incretin system to reduce appetite and improve metabolic signaling

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This will help healthcare providers make better choices

Xie X, Liu H, Wang Y, Zhou Y, Yu H, Li G, Ruan Z, Li F, Wang X, Zhang J (2016) Nicotinamide N-methyltransferase enhances resistance to 5-fluorouracil in colorectal cancer cells through inhibition of the ASK1-p38 MAPK pathway

An analysis of six clinical trials found that AOD 9604 had a safety profile comparable to placebo and did not act through the IGF-1 pathway