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We discuss all the major addictive substances and behaviors, including alcohol, opioids, gambling, stimulants, nicotine, cannabis and more, focusing on how genetics and certain use patterns shape addiction susceptibility

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7 Lower esophageal sphincter abnormalities, increased risk of hiatal hernia, and increased intragastric pressure are other mechanical causes of obesity directly influencing Barretts esophagus and adenocarcinoma

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