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These findings suggest new therapeutic directions targeting Siglec-8 and ROS balance to modulate eosinophil activity and restore intestinal immune homeostasis in IBD

doi: 10.3390/ph14030286 170 KolasinskiSLNeogiTHochbergMCOatisCet GuyattGBlockJet al

Disclosures: Swati Ghosh: Nothing to Disclose, Michael Devereaux: Nothing to Disclose, Aimee Anderson: Nothing to Disclose, COLIN ANDERSON: BioMarin Pharmaceuticals: Employee, ANGELO D'ALESSANDRO: Nothing to Disclose, David Orlicky: Nothing to Disclose, Ronald Sokol: Nothing to Disclose 2474 MACROPHAGE-SPECIFIC HIF1 INHIBITION ACTIVATES HEPATIC STAT6 AND PROTECTS FROM PARENTERAL NUTRITION-ASSOCIATED CHOLESTASIS Swati Ghosh 1 Michael Devereaux 2 Karim el kasmi 2 Ronald Sokol 1 , 1 University of Colorado School of Medicine, 2 University of Colorado School ofMedicine Background: Chronic parenteral nutrition (PN) can lead to PN-associated cholestasis (PNAC)

Key molecular executioners, particularly caspase-1 and MLKL, orchestrate distinct death programs through specific biochemical mechanisms (397)

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