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Relative mRNA expression of Gclm (p = 0.0026), Hmox1 , Nqo1 , and Slc7a11 (d) and representative immunohistochemistry of indicated proteins (e) in Gclc WT and Gclc KO tumors (n = 6 representative from 3 independent experiments)

Similar to cancer cells, immune cells use glutamine metabolites to accelerate the cellular TCA cycle and oxidative phosphorylation processes, thus rapidly obtaining the energy for growth and immune action [54]

Results: In total, 613 of the 702 subjects were enrolled with a mean age of 54.9 11.5 years

Morales et al., 2015)

We selected this threshold (as opposed to the conventional 5E 08 genome-wide significance level) to obtain sufficient SNP instruments for exposures like diet and sleep, which have relatively few significant variants

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