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These inflammatory cytokines and chemokines then recruit more innate immune cells (monocytes, macrophages, neutrophils, DCs, and NK cells) and activate adaptive immune cells (CD4 + and CD8 + T cells) from the peripheral tissues to produce sustained inflammatory cytokines like IL-2, IFN-, and TNF-, which induce myelopoiesis and emergency granulopoiesis that further aggravate lung and epithelial damage (Fig

Additionally, chronic colds, illnesses, toxin exposure (i.e

Nat Neurosci 24:10201034 Ulasov AV, Rosenkranz AA, Georgiev GP, Sobolev AS (2022) Nrf2/keap1/are signaling: towards specific regulation

This anti-inflammatory effect supports long-term health and prevents chronic conditions

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Balanced gut health has been linked to improved digestion, immune function, and general well-being