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Abbreviations AUC: Area under the curve DNR: Do not resuscitate Gln: Glutamine ICU: Intensive care unit ROC: Receiver operating characteristic ROSC: Return of spontaneous circulation SAPS: Simplified Acute Physiology Score SOFA: Sequential Organ Failure Assessment References Tjder I, Rooyackers O, Forsberg AM, Vesali RF, Garlick PJ, Wernerman J

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FIGURE 1 2 The role of sleep in regulating free radicals in the brain: from Reimunds free radical flux theory to modern insights Reimunds free radical flux theory of sleep, proposed in the 1990s, received significant attention for suggesting that ROS accumulate in the brain during wakefulness, when energy consumption is high, and are subsequently cleared during sleep through a scavenging process that also suppresses their production (Reimund, 1994

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