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The disease can occur at any age, with a variety of symptoms/manifestations

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In order for new hair to grow in its place, it grows for a few years (the growth phase), rests for a few months (the resting phase), and finally falls out (the shedding phase)

[13] Focal scoliosis and/or kyphosis are the most common skeletal manifestation of NF-1, occurring in 20% of affected patients

Analytical Characterisation Each batch is analysed using: HPLC for purity assessment Mass spectrometry (MS) for molecular weight confirmation Quality Assurance Batches are produced under controlled laboratory conditions and evaluated against predefined quality criteria to ensure consistency, identity, and purity

After centrifugation at 12000 rpm at room temperature for 10 minutes, the supernatants were transferred into clean tubes containing reagent II for 30 minutes