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Introduction Breast cancer is the most common malignant tumor and the second capital reason for cancer death among women worldwide ( Recently, increasing evidence point out that cancer is not only a genetic disease but also a metabolic disease, in which oncogenic signaling pathways participate in energy regulation and anabolism to support rapidly spreading tumors ( Table 1 )

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In SURMOUNT-1 , a 72-week Phase 3 double-blind trial in 2,539 adults with obesity (or overweight with a complication) but without diabetes, once-weekly tirzepatide produced mean weight changes of 15.0% (5 mg), 19.5% (10 mg), and 20.9% (15 mg) versus 3.1% with placebo, with 5057% of participants on the higher doses losing at least 20% of body weight

Ottawa, ON: University of Ottawa (2015) 7