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The peptide's anti-inflammatory and antimicrobial properties provide additional advantages in chronic wound contexts, where persistent inflammation and bacterial colonization frequently impede repair

Pregnant or breastfeeding women should avoid MOTS-c given the absence of safety data in these populations, as is standard for all investigational peptide therapies

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In human colon cancer cells, silencing NNMT resulted in approximately a 30% increase in NAD + levels (Xie et al., 2014), whereas NNMT overexpression decreased NAD + levels by 30% (Xie et al., 2014)

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Researchers observed that by blocking this enzymatic step, 5-Amino-1MQ may increase the availability of nicotinamide for conversion back to NAD+ through the salvage pathway