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Supporting this, in a microbead mouse model of ocular hypertension (which follows the same principle as for the rat model explained above), hypoxia and an increase in Hif1a labelling were detected in microglia in the optic nerve and ONH (as well as in astrocytes and Mller cells (87)

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10.1016/j.ejphar.2021.174603 204 WeiM.GaoY.ChengD.ZhangH.ZhangW.ShenY.et al (2022)

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We found transcriptionally repressed NAD+ de novo biosynthesis and decreased hepatic NAD+ concentration