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The most consistent results so far are grey matter alterations in the basal ganglia, areas of the limbic system such as the anterior cingulate cortex, hippocampus, insula, etc., and prefrontal areas like the orbitofrontal cortex, sometimes even more pronounced in association with self-reported fatigue or neurocognitive impairment [12, 35, 49]

Some measures, including smoking status and prior competitive sports participation, were qualitative and not assessed through validated questionnaires, which warrants cautious interpretation

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1 H NMR (400 MHz, CDCl 3 ) 3.92 (s, 4H, H 2 -1), 2.85 (s, 8H, H 2 -2)