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NAPDH Oxidase converts oxygen to Super Oxide (O 2 ) mainly in neutrophils Myeloperoxidase (MPO) converts peroxide (H2O2) into Hydrochloric Acid (HOCl) mainly in neutrophils Fenton Reaction generates Hydroxide (OH-) from peroxide (H2O2) using iron Superoxide Dismutase (SOD) converts Super Oxide (O 2 ) to peroxide (H2O2) Glutathione convert Hydroxide (OH-) to water Catalase converts Peroxide (H2O2) to water We will see in the immunology section that that a defect in NADPH Oxidase causes Chronic Granulomatous disease

they create what researchers refer to as a massive immunological "energy sink." Because the immune cells (particularly T-cells and memory lymphocytes) are trapped in a state of severe oxidative stress, they are forced to consume excessive amounts of the host's energy just to survive the ongoing cellular damage and attempt repairs

As mentioned above, membranes can be protected from peroxidation damage via a GSH-dependent lipid peroxide repair system

It has a definite immunosuppressive effect

Zhang Y, Song F, Gao Z, Ding W, Qiao L, Yang S, Chen X, Jin R, Chen D

Pretreatment with phenobarbital, a known P450 inducer, reduces the plasma half-life of the parent compound in both humans and experimental animals