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For people with genetic variants that cause more of an impact on CYP1B1 upregulation combined with an inability to eliminate the estrogen metabolites fast enough (due to phase II genes, diet, and lifestyle) then cigarette smoking is going to significantly increase the bad estrogen metabolites

Standard tirzepatide dosing starts at 2.5 mg weekly for the first four weeks, then increases to 5 mg

A shorter session you can repeat regularly is usually a better idea than treating sauna like a test of grit