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10.2147/NDT.S443278 82 WangX.WeiK.WangM.ZhangL

Loren Pickart, PhD (19382023) Loren Pickart, PhD, was a biochemist at the University of California, San Francisco (UCSF), and the discoverer of GHK-Cu

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By binding copper(II) ions, it helps regulate gene expression linked to collagen formation, angiogenesis, antioxidant defense, and tissue remodeling. The peptides small size allows it to penetrate tissues efficiently, and its copper-transfer activity underlies its reported effects on skin, hair, and wound-healing processes in laboratory models

Gene expression analysis indicated that these suboptimal results were likely due to lower endogenous Nodal signaling and elevated BMP signal activities [1]