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However, the activity reported was very low, which could be enhanced to 963-fold for a triple mutant E423Y/E442Q/D445N of BsGGT, developed by site-directed and random mutagenesis approach (Suzuki et al., 2010)

Taghavi et al., 2017)

In addition, a small pilot safety study published in Alternative Therapies in Health and Medicine showed that intravenous infusions of BPC-157 up to 20 milligrams were well-tolerated with no reported adverse effects in healthy adults, providing initial evidence that the peptide can be administered safely, a necessary step before larger efficacy trials on healing outcomes are conducted

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2010;4 doi: 10.1371/journal.pntd.0000900