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7 Discussion Mn is an essential micronutrient and trace element required for mitochondrial function, antioxidant defense, and cellular metabolism

10.1007/s00253-023-12529-w Appl

A phase I/II clinical trial found that the most common side effects were mild and transient (Teichman et al., 2006): Injection site reactions (redness, mild swelling) Headaches Flushing or warmth Temporary water retention Joint tightness or tingling Transient fatigue or dizziness Serious adverse events are rare when the peptide is used under medical supervision at appropriate doses

Kalantari et al

Second, the core clock components have been observed to act as key molecular players in many intracellular pathways, serving additional physiological roles