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While Mc4r KO mice treated with PL7737 showed no significant decline in food intake or weight, DIO mice treated with PL7737 demonstrated significantly reduced food intake and significantly reduced body weight by 7.06% compared to the vehicle group, confirming the metabolic effects of PL7737 require intact MC4R signaling

Ambroxol Ambroxol, which is an active metabolite of bromhexine, was safely utilized for many years in the management of acute respiratory conditions, like bronchitis and chronic respiratory diseases, as it acts as an expectorant and mucolytic agent [117,118]

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Because of their size and structure, peptides can act like biological signals

PLOS ONE 19 , e0303699