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Zinc-replacement therapy may not reduce oral pain in patients with zinc-deficient burning mouth syndrome (BMS)

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However, using a more stringent inclusion criteria, we identified one well-characterized protein of interest that was both significantly altered in abundance and displayed a large reduction in signal for those affected with konzo, Glutathione Peroxidase 3 (GPx3)

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independent research on oral glutathione has repeatedly found the same pattern, including a frequently cited clinical trial where a single large 3-gram oral dose failed to meaningfully raise blood glutathione levels at all