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Mitochondrial OXPHOS-based ROS accumulation downstream methionine-SAM axis is the causality in the induction of ferroptosis ROS is produced in large quantities as a by-product from electron transfer chain, that contributes to ATP synthesis through oxidative phosphorylation (OXPHOS) in mitochondria

Figure 4 This vertically integrated framework also clarifies the role of shared molecular pathways

To view a copy of this license, visit About this article Cite this article Zhu, H., Cheng, Y., Wang, X

Early glial responses in murine models of multiple sclerosis

Regarding the effects on the peripheral nervous system, protocatechuic acid has only been tested in vitro on the RSC96 Schwann cell line, where it enhanced cell survival, proliferation, and migration [78,79]

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