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sncRNAs are a broad category that includes a wide range of RNA types, such as endo-siRNAs, piRNAs, and miRNAs, all of which are important regulatory factors in the growth and operation of germ cells

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For example, some release only tryptase, and others only chymase (both along with histamine, IL-6, TNF-alpha, prostaglandins, etc.).[ref] Allergens and pathogens cross-link with IgE and activate mast cells

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Treatment should always be based on clinical need rather than perceived benefit