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BMJ 337:a600

Higher GABA activity in the brainstem can reduce the sensitivity of the area postrema to nausea triggers, effectively raising the threshold for how much GLP-1 stimulation is needed before nausea occurs

While these are promising strategies, it is essential that the suggested effects of loss-of-function ATXN3 [71] are well studied in order to evaluate if the beneficial effects outweigh the risks, particularly because ATXN3 gene silencing in some cell types has been shown to cause accumulation of DNA damage, increased proliferation, and loss of adhesion and of differentiation, all of which are hallmarks of cancer [71, 282]

Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy

Oral vitamin C at comparable doses produces gastrointestinal side effects that make high-dose oral supplementation impractical IV delivery bypasses this limitation entirely

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