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Liu J, Sui X, Lavie CJ, Zhou H, Park YM, Cai B, Liu J, Blair SN

The described metabolic and biochemical features underline the risk that they can produce toxic metabolites suh as ammonia and bio-active undesired amines like histamine and tyramine

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Also, infusion of histamine in migraineurs causes a severe pulsating headache compared to controls (Krabbe and Olesen, 1980)

FDAs page lists docket FDA-2025-N-6895 and also references FDA-2026-N-2979

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