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Neuroprotective effects of the novel brain-penetrating pyrrolopyrimidine antioxidants U-101033E and U-104067F against post-ischemic degeneration of nigrostriatal neurons

Effects of ALC Supplementation Neuroprotective effects in brain ischemia Prevention of peripheral nerve damage Effective in the treatment of Parkinsons disease in animal models Reduction of cognitive decline in aging Treatment of Alzheimers disease Effects of Myocardial Ischemia Myocardial ischemia leads to: Reduced carnitine reserves in the heart Accumulation of toxic metabolites of fatty acids in the heart Inhibition of beta-oxidation Reduced ATP production in the myocardium Toxic metabolites (including acylcarnitine and beta-hydroxy-acyl-CoA metabolites) Fatty acids have harmful effects on myocardial recovery during reperfusion

Nakamura, Y., Hirano, S., Suzuki, K

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