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Table-2: Risk factors for toxicity of Paracetamol Mechanism of toxicity Acetaminophen has been postulated to cause liver injury by mechanisms including glutathione depletion, oxidative stress and mitochondrial dysfunction leading to loss of ATP

ABCB4 mutations in the adult population can present with intrahepatic cholelithiasis, PFIC3, ICP, or low phospholipid-associated cholestasis (LPAC) syndrome (Table 1)

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Each liver was then homogenized in a dounce homogenizer (Cole Parmer) with 2 ml of lysis buffer

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