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Of the targeted systemic therapies, a lack of comparative clinical studies further complicates medical treatment decision making as no definitive treatment approach exists

Most excluded studies focused on specific dermatological conditions (acne, psoriasis, radiotherapy-induced dermatitis) rather than addressing general skin health and age-related changes

Of note, ferroptosis likely contributes to unbalanced myeloid/lymphoid lineage differentiation of long-term HSCs via cholesterol-mediated promotion of ferroptosis resistance in a SLC38A9mTOR axis-dependent fashion in a murine model of hypercholesterolemia

Because it works at a cellular level, it takes time for the body to replenish its stores and for those changes to manifest physically