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Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation

A similar effect on MOG + fluorescence intensity was found with a significant effect of treatment on MOG expression, irrespective of time ( p = 0.016) (Figure 2F)

By these manners, NAC can mitigate ROS and inhibit osteoclast differentiation via regulating redox signaling pathways, thereby reducing oxidative stress-mediated bone resorption (Table 3)

Nonetheless, their efficacy is reduced when tested in human subjects, highlighting the need to explore signaling molecules implicated in alternative pathways triggering iron accumulation

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