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These in vitro findings cannot be transferred to the treatment of humans and require further research

While a biphasic kill curve was observed for the metZ treated with BDQ at pH 7.2, the kill curve at pH 5.5 was predominantly linear, suggesting a lower frequency of persisters formation at acidic pH

These therapeutic approaches could also be extended to other neurodegenerative conditions affecting the CNS

This work was supported in part by grants from NIH AG067664, CA252707 and GM157928 to T.G.K., GM146979 to L.W., HL158081 and CA172408 to F.C.Y., and CA279317 to M.A.B., from National Natural Science Foundation of China 82372736 to L.Z., from the Robert H

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