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A recent report demonstrated the existence of a chief-to-oxyphil cell trans-differentiation characterized by gradual mitochondrial enrichment associated with the uremic milieu

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Characterization of the -carotene hydroxylase gene DSM2 conferring drought and oxidative stress resistance by increasing xanthophylls and abscisic acid synthesis in rice.Plant Physiology.2010;154(3):1304-1318 170

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The mechanisms of stress-altered permeability are likely related to changes in tissue perfusion and altered gastrointestinal motility

Vijayakumar et al