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Adequate GSH levels help preserve neuronal integrity, while depletion is a hallmark of neurodegenerative diseases such as Parkinsons and Alzheimers (4849)

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However, CsA exhibits significant intra- and inter-patient pharmacokinetic variabilities and has limited bioavailability

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In a study with volunteers to unravel the differential contributions of theobromine and caffeine on mood, psychomotor performance, and blood pressure, the authors concluded that caffeine might have more CNS-mediated effects on alertness, while theobromine might be acting primarily via peripheral physiological changes [225]

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According to Jiang et al

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