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Figure 1 Ethic statement All procedures were reviewed and approved by the Animal Care and Use Committee of the Yonsei University College of Medicine (Identification code: 2014-0125-3)

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Main functions of Lipotropics Helps lower cholesterol Decreases risk of gallstones Increases resistance to disease Prevents accumulation of fats in the liver Recognizes and destroys foreign and abnormal tissue How does it work

Oxidized lipids activate autophagy in a JNK-dependent manner by stimulating the endoplasmic reticulum stress response

Dapagliflozin ameliorates diabetes-induced spermatogenic dysfunction by modulating the adenosine metabolism along the gut microbiota-testis axis

All libraries were combined (named E1) and used as the initial population for the first round of selections