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The heatmap (Supplementary Figure S1) showed distinct clustering between the two treatment groups, further confirming that the observed metabolic alterations were specific to A45 exposure

First-line treatments usually consist of hormonal treatmentsuch as a hormonal IUD (coil) or continuous use of a birth control pillcombined with a non-steroidal anti-inflammatory drug (NSAID) like naproxen

However, total heme titer of strain BSH11, which we constructed on the basis of BSH8, reached 248.26 6.97 mg/L during fed-batch fermentation with 221.83 4.71 mg/L (89%) of extracellular heme (Yang et al

(ii) hypertrophic cardiomyopathy (HCM), characterised by myocardial thickening