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10.1006/anbo.1995.1100 Ann

Hydroxyl radicals are extremely reactive and may cause extensive damage to cellular components

J Med Genet (2010) 47:1205

Cell 2005

HO-1 catalyzes the degradation of heme into biliverdin, carbon monoxide (CO), and Fe + by reducing the heme-associated ferric iron (Fe + ) to Fe + (30)