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This protein also has the ability to upregulate the expression of the checkpoint inhibitor PD-L1 on the DCs surface [24,63]

Cluster analysis (Figure S5B) demonstrated clear separation between groups: controls clustered with high Bacteroidota/Actinomycetota representation, ASD models formed a distinct Firmicutes-dominated cluster, and hCiPSCs-treated animals occupied an intermediate position

It is also used for its anti-aging properties and to improve skin health, given its role in detoxification and protection against environmental damage

Its ability to reduce brain edema, hemorrhagic lacerations, and subarachnoid bleeding directly counters the most dangerous secondary injury processes

A study (Houtman et al., 2019) shows that BECN1 deficiency enhances IL-1 and IL-18 release from microglia, causing aberrant neuroinflammation and neurodegeneration, potentially linked to high mobility group box 1 (HMGB1) secretion

1/Smad2/3 axis, a key pathway in fibrosis and epithelial-mesenchymal transition, thus reducing tissue fibrosis and promoting regenerative over fibrotic repair 4