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Advanced glycation end products induce oxidative stress and mitochondrial dysfunction in SH-SY5Y cells

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This can disrupt the delicate hormonal signals from the brain (hypothalamus and pituitary gland) to the ovaries, leading to a halt in ovulation and, consequently, missed periods (a condition called hypothalamic amenorrhea)

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The GHK-Cu is released in substantial amounts in 12 hrs

Untreated controls labeled with the vital dye DASPEI display bright neuromast fluorescence (Figure 2A inset)