These design details are crucial for enhancing the success rate of clinical translation of EV therapy for AD
The midstream engineering stage, which serves as the core process for endowing EVs with therapeutic functions, involves two key steps: drug loading and secondary targeting modification
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It is involved in key metabolic pathways, including the tricarboxylic acid cycle, oxidative phosphorylation, and the metabolism of amino acids, fatty acids, and nucleotides (78, 79)
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