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Beyond the synthetic considerations of oligonucleotide modification, critical linker properties such as length 22 , attachment site 23,24,25 , hydrophobicity 22 , chemical stability 26,27 and immunogenicity 28,29 heavily impact the performance of the final conjugate

doi: 10.3390/ijms19092563, 56

Increased TNF- is closely linked to the delayed wound healing processes and failure to develop the granulation tissue