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In the STEP-4 clinical trials, participants who discontinued the medication began to regain weight within a few months

A large study of 2,000 obese adults found that participants using semaglutide combined with diet and exercise lost up to 15-20% of their body weight after 68 weeks

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The increase in circulating cobalamin levels is predominantly caused by enhanced production of haptocorrin.Several liver diseases like acute hepatitis, cirrhosis, hepatocellular carcinoma and metastatic liver disease can also be accompanied by an increase in circulating cobalamin

Many dietary supplements also claim to aid weight loss, but their efficacy and safety are often questionable