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UltaLabTests)

Hepatocyte pyroptosis promotes macrophages M1 polarization to aggravate acute liver injury

Kidney-targeted delivery systemssuch as PEGylated lipid nanoparticles (LNPs) modified with renal tubular cell-targeting ligands (e.g., vitamin B12, which binds to cubilin on PT cells)have shown promise in preclinical studies, increasing renal Fer-1 accumulation by 510-fold and reducing systemic toxicity

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