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Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

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The core structure of the hexamer is a stacked dimer of trimers

These insults lead to the release of damage-associated molecular patterns (DAMPs), including high mobility group box 1, heat shock proteins, S100 proteins, and ATP, which activate innate immune components such as Kupffer cells, neutrophils, natural killer cells, natural killer T cells, and mast cells