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An active drug may be converted to an active or toxic metabolite

Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, hinges on core redox regulators such as the glutathione (GSH)/glutathione GPX4 axis, making it a compelling therapeutic target across diverse cancer contexts (Ji et al., 2022

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Anti-inflammatory agents can reduce the neuroinflammation often observed in AD, and compounds that enhance cholinergic transmission can address the neurotransmitter deficits associated with cognitive decline

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OUD participants were also current smokers ( n = 8), current marijuana users ( n = 7), current ( n = 4) or past ( n = 3) cocaine users, current ( n = 2) or past ( n = 1) amphetamine users, and past LSD users ( n = 2)