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Finally, determining how to felicitously use cytotoxic autophagy to kill GBM cells or inhibit protective autophagy, and ameliorating the autophagy-related drug tolerance caused by long-term administration of anti-glioma drugs, are still the two primary problems that remain to be solved

2020;53:e9211

ISO100's protein count of 25g per serving hits the research-consistent dose range for maximizing muscle protein synthesis from a single protein feeding the dose at which leucine-triggered mTOR signaling reaches near-maximal activation. The 5.5g BCAA total includes 2.7g of Leucine specifically Leucine is the individual amino acid most directly responsible for activating the mTOR anabolic pathway, and 2.5-3g of Leucine per dose is the threshold consistently identified in the literature for producing the full anabolic signal. ISO100 meets this threshold in a single serving from the protein alone, before adding any additional EAA or BCAA supplementation.

Leboeuf, RC Modulation of adipose tissue lipolysis and body weight by high-density lipoproteins in mice Nutr Diabetes 4 e108

Cell Res (2021) 31:10725

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