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4 The resulting energy deficit and accumulation of damaged mitochondria contribute to neuronal degeneration and loss of nerve fibers

This was associated with substantive mobility of the RAMP2 linker and TM helix, which had weaker interaction with the CTR TM bundle compared to RAMP1 and RAMP3 in AMY 1 R and AMY 3 R complexes

A gradual increase in drug dosage over time has been shown to reduce these side effects

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