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In typical cases, no biopsy is required

doi: 10.1001/jamapediatrics.2013.4914

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Moreover, higher hypoxia signals and expression of hypoxia-related genes tend to occur in tumors with high heterogeneity and are associated with poor prognosis and tumor progression ( + /H + exchanger NHE1, etc.) are upregulated by HIF-1 ( 2.1.2 Acidity The acid microenvironment is another important feature of the tumors physical microenvironment

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