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Amylin, a neuroendocrine anorexigenic polypeptide hormone, with its multi-faceted effects in glucose regulation, weight management and potential CV and neuroprotective functions, represents an attractive new therapeutic target, albeit not without challenges and limitations [29]

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doi: 10.3389/fchem.2025.1479763 Received 12 August 2024 Accepted 06 January 2025 Published 04 February 2025 Volume 13 - 2025 Edited by Liqun Zhang, University of Rhode Island, United States Reviewed by Mariangela Agamennone, University of Studies G

Research shows tesofensine differentially modulates neuronal ensembles and population activity in the lateral hypothalamus, with greater weight loss effects observed in obese rats compared to lean rats