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The amount of homocysteine in the blood is regulated by at least four vitamins: folate, vitamin B 6 , riboflavin, and vitamin B 12 (see Figure 1 )

Vegans and vegetarians are naturally at higher risk since B12 comes mainly from animal products

10.1007/s10545-017-0063-1 27 LeeB

This is uncommon but occasionally reported anecdotally, particularly at very high doses