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Quickstart Highlights FOXO4-DRI (also known as Proxofim) is a synthetic D-retro-inverso peptide designed to selectively induce apoptosis in senescent cells by disrupting the FOXO4p53 protein interaction [1] [2]

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) activation occurs through both PERK and IRE1 pathways, increasing inflammatory cytokine production

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Finally, as shown in Figure 8D, the group treated with the 40% stretched membrane combined with electrical stimulation displays the thickest granulation tissue on day 14, confirming its substantial effect in promoting structural tissue repair (Wang et al., 2021)