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The yellowish color is removed when the production of red blood cells is stable

In animal studies, AOD-9604 reduced body weight gain by over 50% in obese mice during a 19-day treatment period, and significantly increased fat oxidation all without affecting insulin sensitivity or glucose regulation.[1,3] A randomized controlled trial in humans found that participants taking 1 mg of AOD-9604 daily lost an average of 2.8 kg (~6 lbs) over 23 weeks, compared to 0.8 kg (~1.7 lbs) in the placebo group

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Hepatic Safety Hepatic safety has been a particular focus of attention for orforglipron given the hepatotoxicity findings that led to the discontinuation of two competing oral small-molecule GLP-1 programs