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Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis

Oxidative stress rises and can also trigger refractory epilepsy

Traditional methods can be disheartening or ineffective for those with certain medical conditions or diet restrictions

Excessive depletion of ROS may also be detrimental, as basal ROS levels are indispensable for fundamental physiological processes such as cell proliferation, immune activation, angiogenesis, and tissue remodeling

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This may be explained by differences in body composition and should be taken into account when dosing or following factor VIII levels in the pediatric population.4 Because clearance (based on per kg body weight) has been demonstrated to be higher in the pediatric population, dose adjustment or more frequent dosing based on per kg body weight may be needed in this population [see Clinical Pharmacology (12.3)]