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The anti-inflammatory effects of AC have been strongly related to its antioxidant role, where in an osteoarthritis rat model, the reduction in NF-B was accompanied by diminished reactive oxygen species (ROS) production (Ma et al

10.1242/dev.040055 62 LeblondC

20 Astroglial reactivity can now be defined as an evolutionarily conserved, graded, and multi-stage primarily defensive reaction of astrocytes to neuropathology

PubMed Central, Overgaard, Ulrik M., et al

Importantly, when ascorbate donates an electron and becomes itself oxidized, or "consumed," the ascorbate radical is relatively harmless

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