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Here, we show that treatment of cells with ENDO3 for as short as 2 h induced a significant increase in endolysosome size that recapitulated the phenotype observed in Munc13-4-KO cells (Fig

1992 and citations therein)

Despite these advances, several critical questions remain unresolved

19 the remainder had partial deletion (46 del[X]), an isochromosome of the long arm of one X chromosome (46 X i[Xq]), or mosaics for 45 X with one or more cell lineages